(1R,2R)-ML-SI3( —— )

Catalog No. M35635 CAS No. 2418594-00-8

(1R,2R)-ML-SI3 ((-)-trans-ML-SI3) is a selective TRPML1, TRPML2, and TRPML3 inhibitor for the study of neurodegenerative and cardiovascular diseases.

Purity : >98% (HPLC)

COA

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HNMR

HPLC

MSDS

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Biological Information

Product Name

(1R,2R)-ML-SI3
Note

Research use only, not for human use.
Brief Description

(1R,2R)-ML-SI3 ((-)-trans-ML-SI3) is a selective TRPML1, TRPML2, and TRPML3 inhibitor for the study of neurodegenerative and cardiovascular diseases.
Description

(1R,2R)-ML-SI3 is a potent inhibitor of both TRPML1 and TRPML2 (IC50 values of 1.6 and 2.3 μM) and a weak inhibitor (IC50 12.5 μM) of TRPML3.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

2418594-00-8
Formula Weight

429.58
Molecular Formula

C23H31N3O3S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (232.79 mM; Ultrasonic )
SMILES

N(S(=O)(=O)C1=CC=CC=C1)[C@H]2[C@@H](CCCC2)N3CCN(CC3)C4=C(OC)C=CC=C4
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Leser C, Keller M, Gerndt S, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021;210:112966. ?

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