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KRN2 bromide
CAS No. 1390654-28-0
KRN2 bromide( —— )
Catalog No. M26272 CAS No. 1390654-28-0
KRN2 bromide is a selective NFAT5 inhibitor with an IC50 of 100 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 57 | In Stock |
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| 2MG | 31 | In Stock |
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| 5MG | 49 | In Stock |
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| 10MG | 85 | In Stock |
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| 25MG | 187 | In Stock |
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| 50MG | 299 | In Stock |
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| 100MG | 485 | In Stock |
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| 200MG | 691 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameKRN2 bromide
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NoteResearch use only, not for human use.
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Brief DescriptionKRN2 bromide is a selective NFAT5 inhibitor with an IC50 of 100 nM.
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DescriptionKRN2 bromide is a selective NFAT5 inhibitor with an IC50 of 100 nM. (In Vitro):KRN2 bromide inhibits the NF-κB p65 binding to Nfat5 promoter 1 in a dose-dependent manner and directly blocks the interaction between NF-κB p65 and its DNA binding sequence in the upstream site (base pairs -3000 to +1) of Nfat5 exon 1. KRN2 bromide selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6, without hampering high-salt-induced NFAT5 and its target gene expressions.(In Vivo):In DBA/1J mice immunized with bovine type II collagen, KRN2 bromide (3 mg/kg, i.p.) effectively suppresses CIA as well as AIA in which innate immune cells play a predominant role, and decreases the production of pro-inflammatory cytokines and autoantibodies as well as macrophage infiltration.
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In VitroKRN2 selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6, without hampering high-salt-induced NFAT5 and its target gene expressions.KRN2 dose-dependently inhibits the NF-κB p65 binding to Nfat5 promoter 1 and directly blocks the interaction between NF-κB p65 and its DNA binding sequence in the upstream site (base pairs -3000 to +1) of Nfat5 exon 1.
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In VivoKRN2 (3 mg/kg, i.p., daily for 2 weeks) effectively suppresses AIA in which innate immune cells play a predominant role.KRN2 (3 mg/kg, i.p., daily) effectively suppresses CIA as well as AIA in mice, decreasing the production of pro-inflammatory cytokines and autoantibodies as well as macrophage infiltration. Animal Model:8-week-old C57BL/6 mice injected intradermally with 2 mg of complete Freund's adjuvant.Dosage:3 mg/kg.Administration:Peritoneally (i.p.) daily for 2 weeks.Result:Effective in suppressing AIA.Animal Model:8-week-old DBA/1J mice immunized with bovine type II collagen.Dosage:3 mg/kg.Administration:Peritoneally (i.p.) daily.Result:Effective in suppressing CIA as well as AIA in mice, decreasing the production of pro-inflammatory cytokines and autoantibodies as well as macrophage infiltration.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorCaspase-3
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Research Area——
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Indication——
Chemical Information
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CAS Number1390654-28-0
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Formula Weight524.386
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Molecular FormulaC27H23BrFNO4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 18.33 mg/mL (34.96 mM)
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SMILES[Br-].COc1ccc2c(Cc3ccccc3F)c3-c4cc5OCOc5cc4CC[n+]3cc2c1OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ahmed R Alsuwaidi, et al. Lung tissue bioenergetics and caspase activity in rodents. BMC Res Notes. 2013; 6: 12.
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