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Mardepodect hydrochloride
CAS No. 2070014-78-5
Mardepodect hydrochloride( —— )
Catalog No. M35633 CAS No. 2070014-78-5
Mardepodect hydrochloride (Mardepodect HCl) is an orally active, selective and potent inhibitor of PDE10A that crosses the blood-brain barrier (IC50: 0.37 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 237 | In Stock |
|
| 5MG | 189 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMardepodect hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionMardepodect hydrochloride (Mardepodect HCl) is an orally active, selective and potent inhibitor of PDE10A that crosses the blood-brain barrier (IC50: 0.37 nM).
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DescriptionMardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs. Mardepodect hydrochloride can cross the blood-brain barrier.
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In Vitro——
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In VivoIn the conditioned avoidance response assay (CAR), Mardepodect (PF-2545920) is active with an ED50 of 1 mg/kg. Administration of Mardepodect (PF-2545920) to mice causes a dose dependent increase in striatal cGMP.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis | PDE
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Research Area——
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Indication——
Chemical Information
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CAS Number2070014-78-5
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Formula Weight428.91
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Molecular FormulaC25H21ClN4O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (58.29 mM; Ultrasonic (<60°C)
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SMILESCl.Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wilson JM et al. Phosphodiesterase 10A inhibitor, MP-10 (PF-2545920), produces greater induction of c-Fos in D2 neurons than in D1 neurons in the neostriatum. Neuropharmacology. 2015 Dec;99:379-86.?
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