Enbezotinib( —— )

Catalog No. M35628 CAS No. 2359649-81-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Enbezotinib
Note

Research use only, not for human use.
Brief Description

Enbezotinib is an inhibitor of RET autophosphorylation and can be used in cancer research.
Description

Enbezotinib, an inhibitor of RET, can inhibit the RET autophosphorylation. Enbezotinib can be used for the research of cancer.
In Vitro

Enbezotinib (compound 5) (0.3-300 nM) inhibits p-RET (y905) in RET-driven cells.
In Vivo

Enbezotinib (compound 5) (2-5 mg/kg; twice daily for 27 days) decreases tumor size in mice.
Synonyms

——
Pathway

Tyrosine Kinase
Target

c-RET
Recptor

c-RET
Research Area

——
Indication

——

CAS Number

2359649-81-1
Formula Weight

424.43
Molecular Formula

C21H21FN6O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (235.61 mM; Ultrasonic (<80°C)
SMILES

[H][C@]12CCC[C@@]1([H])N1Cc3cc(F)cnc3O[C@@H](C)CNC(=O)c3cnn4cc(O2)c1nc34
Chemical Name

——

1. ROGERS EW, et, al. Macrocyclic compounds for treating disease. WO2019126121A1.

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