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MK-28
CAS No. 864388-65-8
MK-28( —— )
Catalog No. M35599 CAS No. 864388-65-8
MK-28 is a selective PERK agonist that reduces toxicity and prolongs survival in a Huntington's disease model.MK-28 has a significant killing effect on MK28 gastric cancer cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 258 | In Stock |
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| 5MG | 235 | In Stock |
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| 10MG | 376 | In Stock |
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| 25MG | 728 | In Stock |
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| 50MG | 1079 | In Stock |
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| 100MG | 1609 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMK-28
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NoteResearch use only, not for human use.
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Brief DescriptionMK-28 is a selective PERK agonist that reduces toxicity and prolongs survival in a Huntington's disease model.MK-28 has a significant killing effect on MK28 gastric cancer cells.
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DescriptionMK-28 is a potent and selective PERK activator. MK-28 exhibits remarkable pharmacokinetic properties and high BBB penetration in mice.
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In VitroMK-28 (0-100 μM) shows PERK selectivity in vitro on a 391-kinase panel and rescues cells (but not PERK?/? cells) from ER stress-induced apoptosis.ATF4 protein levels are increased signifcantly, up to 2.5-fold, in STHdhQ111/111 cells at high MK-28 concentration. CHOP and GADD34 mRNA levels show a signifcant increase in both cell types, up to 10- and 5-fold respectively.MK-28 has little or no efect on EIF2AK1 (HRI) or EIF2AK2 (PKR), but it activats EIF2AK4 (GCN2).Apoptosis Analysis.Cell Line:STHdhQ111/111 cells.Concentration:0-100 μM.Incubation Time:48 h.Result:Rescued cells from ER stress-induced apoptosis.
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In VivoMK-28 (10 mg/kg, IP, single dose) shows a maximum concentration (Cmax) of 105ng/ml and 30min half-life in plasma, 40 min afer the IP injection.MK-28 (1 mg/kg, IP, daily for 28 days) improves systemic function and survival in R6/2 mice and induces increased levels of eIF2α-P in the mouse brain striatum.MK-28 (Transient subcutaneous delivery) significantly improves motor and executive functions and delayed death onset in R6/2 mice, showing no toxicity.Animal Model:R6/2 mice.Dosage:1 mg/kg.Administration:IP, daily for 28 days.Result:Incerased the survival.
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Synonyms——
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PathwayApoptosis
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TargetPERK
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RecptorPERK | Antiviral
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Research Area——
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Indication——
Chemical Information
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CAS Number864388-65-8
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Formula Weight396.44
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Molecular FormulaC24H20N4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 12.5 mg/mL (31.53 mM; Ultrasonic )
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SMILESCN(\N=C\c1ccc(O)c(O)c1)c1nc(cc(n1)-c1ccccc1)-c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Javier Ganz, et al. A novel specific PERK activator reduces toxicity and extends survival in Huntington's disease models. Sci Rep. 2020 Apr 23;10(1):6875.?
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