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Rineterkib
CAS No. 1715025-32-3
Rineterkib( LTT-462 | ERK-IN-1 )
Catalog No. M26206 CAS No. 1715025-32-3
Rineterkib is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 236 | In Stock |
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| 5MG | 179 | In Stock |
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| 10MG | 335 | In Stock |
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| 25MG | 568 | In Stock |
|
| 50MG | 791 | In Stock |
|
| 100MG | 1070 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRineterkib
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NoteResearch use only, not for human use.
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Brief DescriptionRineterkib is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.
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DescriptionRineterkib is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.(In Vivo):In the Calu-6 human NSCLC subcutaneous tumor xenograft model, Rineterkib (50, 75 mg/kg, p.o.) treatment significantly reduces the tumor volume.
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In Vitro——
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In VivoAnimal Model:Calu-6 NSCLC xenograft tumor models in mice.Dosage:50, 75 mg/kg.Administration:Orally either daily (qd) or every other day (q2d) for 27 days.Result:Significantly reduced the tumor volume.
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SynonymsLTT-462 | ERK-IN-1
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PathwayApoptosis
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TargetPERK
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Recptorβ-adrenoceptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1715025-32-3
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Formula Weight578.434
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Molecular FormulaC26H27BrF3N5O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 200 mg/mL (345.77 mM)
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SMILESCNC[C@@H](NC(=O)c1ccc(cc1F)-c1nc(cnc1N)[C@H]1CC[C@H](O)[C@@H](F)C1)c1cc(F)cc(Br)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Cocker PJ, Lin MY, Tremblay M, Kaur S, Winstanley CA. The β-adrenoceptor blocker propranolol ameliorates compulsive-like gambling behaviour in a rodent slot machine task:implications for iatrogenic gambling disorder. Eur J Neurosci. 2018 Jul 17.
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