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Home - Products - Apoptosis - PERK - Rineterkib

Rineterkib

CAS No. 1715025-32-3

Rineterkib( LTT-462 | ERK-IN-1 )

Catalog No. M26206 CAS No. 1715025-32-3

Rineterkib is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 236 In Stock
5MG 179 In Stock
10MG 335 In Stock
25MG 568 In Stock
50MG 791 In Stock
100MG 1070 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Rineterkib
  • Note
    Research use only, not for human use.
  • Brief Description
    Rineterkib is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.
  • Description
    Rineterkib is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.(In Vivo):In the Calu-6 human NSCLC subcutaneous tumor xenograft model, Rineterkib (50, 75 mg/kg, p.o.) treatment significantly reduces the tumor volume.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Calu-6 NSCLC xenograft tumor models in mice.Dosage:50, 75 mg/kg.Administration:Orally either daily (qd) or every other day (q2d) for 27 days.Result:Significantly reduced the tumor volume.
  • Synonyms
    LTT-462 | ERK-IN-1
  • Pathway
    Apoptosis
  • Target
    PERK
  • Recptor
    β-adrenoceptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1715025-32-3
  • Formula Weight
    578.434
  • Molecular Formula
    C26H27BrF3N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 200 mg/mL (345.77 mM)
  • SMILES
    CNC[C@@H](NC(=O)c1ccc(cc1F)-c1nc(cnc1N)[C@H]1CC[C@H](O)[C@@H](F)C1)c1cc(F)cc(Br)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Cocker PJ, Lin MY, Tremblay M, Kaur S, Winstanley CA. The β-adrenoceptor blocker propranolol ameliorates compulsive-like gambling behaviour in a rodent slot machine task:implications for iatrogenic gambling disorder. Eur J Neurosci. 2018 Jul 17.
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