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Tovinontrine
CAS No. 2062661-53-2
Tovinontrine( —— )
Catalog No. M35598 CAS No. 2062661-53-2
Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 274 | In Stock |
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| 5MG | 250 | In Stock |
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| 10MG | 359 | In Stock |
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| 25MG | 581 | In Stock |
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| 50MG | 761 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTovinontrine
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NoteResearch use only, not for human use.
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Brief DescriptionTovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.
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DescriptionTovinontrine (IMR-687) is a highly potent and selective phosphodiesterase-9 (PDE9) inhibitor specifically for the treatment of sickle cell disease. IC50s are 8.19 nM and 9.99 nM for PDE9A1 and PDE9A2, respectively.
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In Vitro——
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In VivoAnimal Model:HbSS-Townes mice on a 129/B6 background (10-12 weeks old) Dosage:30 mg/kg Administration:Dosed daily by gavage for 30 days Result:Resulted in fetal hemoglobin (HbF) induction, reduced hemolysis and reduced reticulocytosis.
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Synonyms——
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE
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Research Area——
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Indication——
Chemical Information
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CAS Number2062661-53-2
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Formula Weight394.47
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Molecular FormulaC21H26N6O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (253.50 mM; Ultrasonic )
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SMILESC[C@@H]1CN(Cc2ncccn2)C[C@H]1c1cn2c(ncc2c(=O)[nH]1)C1CCOCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. James G McArthur, et al.A novel, highly potent and selective phosphodiesterase-9 inhibitor for the treatment of sickle cell disease. Haematologica. 2020 Mar;105(3):623-631.?
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