HIF-1α-IN-2

Research use only, not for human use.

HIF-1α-IN-2 is a novel and highly potent HIF-1α inhibitor with anticancer and antitumor activity that inhibits the expression of HIF-1α and VEGF in a dose-dependent manner and inhibits cell migration.

HIF-1α-IN-2 is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 suppresses HIF-1α expression by blocking transcription and protein translation.

Cell Viability Assay Cell Line:MDA-MB-231 cells, MiaPaCa-2 cells Concentration:5 μM Incubation Time:72 hours Result:Suppressed the viability of these two cell lines with IC50 of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively.Cell Viability Assay Cell Line:MDA-MB-231 cells, MiaPaCa-2 cells Concentration:5 μM Incubation Time:72 hours Result:Suppressed the viability of these two cell lines with IC50 of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively.

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Angiogenesis

HIF/HIF Prolyl-hydroxylase

HIF

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2762315-06-8

361.46

C21H19N3OS

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (69.16 mM; Ultrasonic (<60°C)

COc1ccc2c(Nc3cccc(c3)-c3csc(C)n3)cc(C)nc2c1

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(-20℃)

With Ice Pack

≥ 2 years