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Home - Products - Membrane Transporter/Ion Channel - NADPH - HTS07545

HTS07545

CAS No. 118666-03-8

HTS07545( —— )

Catalog No. M35541 CAS No. 118666-03-8

HTS07545 is a potent sulfide:quinone oxidoreductase inhibitor (IC50: 30 nM) that reduces the rate of hydrogen sulfide (H2S) decomposition and has been used in heart failure studies.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HTS07545
  • Note
    Research use only, not for human use.
  • Brief Description
    HTS07545 is a potent sulfide:quinone oxidoreductase inhibitor (IC50: 30 nM) that reduces the rate of hydrogen sulfide (H2S) decomposition and has been used in heart failure studies.
  • Description
    HTS07545 is a potent sulfide:quinone oxidoreductase (SQOR) inhibitor with an IC50 of 30 nM. HTS07545 decrease the rate of breakdown of hydrogen sulfide (H2S). HTS07545 can be used for heart failure research.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NADPH
  • Recptor
    NADPH
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    118666-03-8
  • Formula Weight
    358.39
  • Molecular Formula
    C22H18N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (279.03 mM; Ultrasonic )
  • SMILES
    C(#N)C=1C(=CC(=NC1OCC(OCC)=O)C2=CC=CC=C2)C3=CC=CC=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Simon D P Baugh, et al. Synthesis and evaluation of potent novel inhibitors of human sulfide:quinone oxidoreductase. Bioorg Med Chem Lett. 2021 Dec 15;54:128443. ?
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