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Home - Products - Membrane Transporter/Ion Channel - P2X Receptor - GSK-1482160

GSK-1482160

CAS No. 1001389-72-5

GSK-1482160( —— )

Catalog No. M35501 CAS No. 1001389-72-5

GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 30 In Stock
5MG 29 In Stock
10MG 44 In Stock
25MG 89 In Stock
50MG 154 In Stock
100MG 228 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    GSK-1482160
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity.
  • Description
    GSK-1482160 is an orally available negative allosteric modulator of the P2X7 receptor. P2X7 receptors are involved in the production of pro-inflammatory cytokines, such as Il-1β, by central and peripheral immune cells. GSK-1482160 has the potential for the research of inflammation diseases.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    P2X Receptor
  • Recptor
    P2X Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1001389-72-5
  • Formula Weight
    334.72
  • Molecular Formula
    C14H14ClF3N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (298.76 mM; Ultrasonic )
  • SMILES
    CN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ali Z, et al. Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects. Br J Clin Pharmacol. 2013;75(1):197-207. doi:10.1111/j.1365-2125.2012.04320.x
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