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Home - Products - Metabolic Enzyme/Protease - MAO - AChE/BChE/MAO-B-IN-1

AChE/BChE/MAO-B-IN-1

CAS No. 2416910-82-0

AChE/BChE/MAO-B-IN-1( —— )

Catalog No. M35486 CAS No. 2416910-82-0

AChE/BChE/MAO-B-IN-1 is a reversible, non-time-dependent inhibitor of AChE, BChE, and MAO-B that crosses the blood-brain barrier, exhibiting inhibitory effects on hAChE, hBChE, and hMAO-B with IC50s of 7.31, 0.56, and 26.1 μM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AChE/BChE/MAO-B-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    AChE/BChE/MAO-B-IN-1 is a reversible, non-time-dependent inhibitor of AChE, BChE, and MAO-B that crosses the blood-brain barrier, exhibiting inhibitory effects on hAChE, hBChE, and hMAO-B with IC50s of 7.31, 0.56, and 26.1 μM, respectively.
  • Description
    AChE/BChE/MAO-B-IN-1 (Compound 10) is a reversible and non-time-dependent AChE, BChE and MAO-B inhibitor with IC50 values of 7.31, 0.56 and 26.1 μM for hAChE, hBChE and hMAO-B, respectively. AChE/BChE/MAO-B-IN-1 can cross the BBB and shows neuroprotective effects without cytotoxicity.
  • In Vitro
    AChE/BChE/MAO-B-IN-1 (Compound 10) prevents amyloid β1-42 (Aβ1-42)-induced neuronal cell death.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    MAO
  • Recptor
    MAO | AChE
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2416910-82-0
  • Formula Weight
    324.42
  • Molecular Formula
    C20H24N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(N1CCC(COC(NC2=CC=CC=C2)=O)CC1)C3=CC=CC=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ko?ak U, et al. N-alkylpiperidine carbamates as potential anti-Alzheimer's agents. Eur J Med Chem. 2020 Jul 1;197:112282. ?
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