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DDO-7263
CAS No. 2254004-96-9
DDO-7263( —— )
Catalog No. M35426 CAS No. 2254004-96-9
DDO-7263 is a 1,2,4-Oxadiazole derivative that upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 5MG | 93 | In Stock |
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| 10MG | 147 | In Stock |
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| 25MG | 246 | In Stock |
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| 50MG | 323 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameDDO-7263
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NoteResearch use only, not for human use.
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Brief DescriptionDDO-7263 is a 1,2,4-Oxadiazole derivative that upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2.
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DescriptionDDO-7263, a 1,2,4-Oxadiazole derivative, is a potent Nrf2-ARE activator. DDO-7263 upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 induces Nrf2 translocation into the nucleus. DDO-7263 inhibits of NLRP3 inflammasome activation. DDO-7263 exerts anti-inflammatory activity and has the potential for neurodegenerative diseases research, such as Parkinson's disease (PD).
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In VitroWestern Blot AnalysisCell Line:PC12 cells Concentration:20 μM Incubation Time:2, 4, 8, 12, 24 hours Result:Upregulated the protein levels of HO-1 and NQO1 in concentration-dependent manners.
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In VivoAnimal Model:Male C57BL/6 mice at 10 weeks of age and body weights of 22-26 gDosage:10, 50, 100 mg/kg Administration:IP; daily for 10 days Result:Improved the reduction of vertical spontaneous activity and mitigated the loss of balance coordination caused by MPTP (20 mg/kg/day; 7 days). Protected dopaminergic neurons from MPTP. Significantly downregulated the levels of pro-inflammatory factors, including IL-1β and TNF-α, in mouse plasma.Animal Model:SD rats Dosage:7, 35, 70 mg/kg (Pharmacokinetic Analysis) Administration:IP Result:Had a T1/2 of 3.32 hours and a Cmax of 1.38 mg/mL.
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Synonyms——
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PathwayNuclear Receptor/Transcription Factor
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TargetKeap1-Nrf2
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RecptorNrf2
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Research Area——
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Indication——
Chemical Information
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CAS Number2254004-96-9
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Formula Weight273.24
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Molecular FormulaC14H9F2N3O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 17.86 mg/mL (65.36 mM; Ultrasonic (<60°C)
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SMILESCc1ccc(cn1)-c1noc(n1)-c1ccc(F)c(F)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li-Li Xu, et al. 5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress. Free Radic Biol Med. 2019 Apr;134:288-303.?
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