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PXS-6302 hydrochloride

CAS No. 2584947-79-3

PXS-6302 hydrochloride( —— )

Catalog No. M35419 CAS No. 2584947-79-3

PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3.7 μM, 3.4 μM, 0.4 μM, 1.5 μM, and 0.3 μM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PXS-6302 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3.7 μM, 3.4 μM, 0.4 μM, 1.5 μM, and 0.3 μM, respectively.
  • Description
    PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor with IC50s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 hydrochloride has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Porcine excision injury model (female Juvenile pigs, 18-20 kg).Dosage:0.5, 1.5, or 3%, oil in water cream; 400 mg cream applied to 16 cm2 Administration:External application; 1, 2 and 3 weeks post-injury; once dayly, for 12 weeks Result:Showed significantly higher scores for the 3% treated scars suggesting significant improvement in scar appearance.
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    Lipoxygenase
  • Recptor
    Lipoxygenase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2584947-79-3
  • Formula Weight
    301.71
  • Molecular Formula
    C10H11ClF3NO2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    S(C(/C(=C/CN)/F)(F)F)(=O)(=O)C1=CC=CC=C1.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chaudhari N, et al. Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis. Nat Commun. 2022 Sep 22;13(1):5555.?
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