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11β-HSD1-IN-11
CAS No. 859721-81-6
11β-HSD1-IN-11( —— )
Catalog No. M35344 CAS No. 859721-81-6
11β-HSd1-in-11 is a potent and competitive inhibitor of 11-β-hydroxysteroid dehydrogenase 1 (11β-HSD1) IN rats and humans with IC50 values of 0.34 μM and 0.13 μM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 252 | In Stock |
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| 5MG | 255 | In Stock |
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| 10MG | 375 | In Stock |
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| 25MG | 562 | In Stock |
|
| 50MG | 770 | In Stock |
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| 100MG | 1051 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2111 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name11β-HSD1-IN-11
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NoteResearch use only, not for human use.
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Brief Description11β-HSd1-in-11 is a potent and competitive inhibitor of 11-β-hydroxysteroid dehydrogenase 1 (11β-HSD1) IN rats and humans with IC50 values of 0.34 μM and 0.13 μM, respectively.
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Description11β-HSD1-IN-11 (Compound c1a) is a competitive 11β-HSD1 inhibitor with IC50s of 0.34 μM and 0.13 μM against rat and human 11β-HSD1, respectively.
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In Vitro——
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In VivoA single dose of the 11β-HSD1 inhibitor Merck 544 reduced the overall abundance of 11β-HSD1-IN-11 (Compound c1a) (15 mg/kg; oral gavage; once) in the rat liver.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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RecptorDehydrogenase
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Research Area——
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Indication——
Chemical Information
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CAS Number859721-81-6
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Formula Weight328.31
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Molecular FormulaC15H11F3O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESS(CC(=O)C1=CC=C(C(F)(F)F)C=C1)(=O)(=O)C2=CC=CC=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Naredo-Gonzalez G, et al. Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19F-Magnetic Resonance Spectroscopy. Sci Rep. 2022 Sep 29;12(1):16268.?
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