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Home - Products - Chromatin/Epigenetic - Sirtuin - ADTL-SA1215

ADTL-SA1215

CAS No. 782387-91-1

ADTL-SA1215( —— )

Catalog No. M35238 CAS No. 782387-91-1

ADTL-SA1215 is a selective SIRT3 activator with SIRT3 deacetylase activity that inhibits the proliferation and migration of human breast cancer MDA-MB-231 cells through the SIRT3-driven autophagy/mitochondrial autophagy signaling pathway, and can be used in the study of triple negative breast cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ADTL-SA1215
  • Note
    Research use only, not for human use.
  • Brief Description
    ADTL-SA1215 is a selective SIRT3 activator with SIRT3 deacetylase activity that inhibits the proliferation and migration of human breast cancer MDA-MB-231 cells through the SIRT3-driven autophagy/mitochondrial autophagy signaling pathway, and can be used in the study of triple negative breast cancer.
  • Description
    ADTL-SA1215 is a first-in-class specific small-molecule activator of SIRT3 that modulates autophagy in triple negative breast cancer.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Sirtuin
  • Recptor
    Sirtuin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    782387-91-1
  • Formula Weight
    657.32
  • Molecular Formula
    C26H29I2NO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (152.13 mM; Ultrasonic (<60°C)
  • SMILES
    CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCCN2CCCC2)c(I)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhang J, et al. Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer. J Med Chem. 2021 Oct 14;64(19):14192-14216. ?
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