5-Hydroxymethyl-2-deoxycytidine( —— )

Catalog No. M35230 CAS No. 7226-77-9

5-Hydroxymethyl-2'-deoxycytidine is an oxidized derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA, causing DNA damage reactions, chromosomal aberrations, replication fork damage, and loss of cell viability.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

5-Hydroxymethyl-2-deoxycytidine
Note

Research use only, not for human use.
Brief Description

5-Hydroxymethyl-2'-deoxycytidine is an oxidized derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA, causing DNA damage reactions, chromosomal aberrations, replication fork damage, and loss of cell viability.
Description

5-Hydroxymethyl-2’-deoxycytidine (5hmdC) is an oxidation derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA. 5-Hydroxymethyl-2’-deoxycytidine may serve as a marker of irreversibly damaged cells.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

PARP
Recptor

PARP
Research Area

——
Indication

——

Chemical Information

CAS Number

7226-77-9
Formula Weight

257.24
Molecular Formula

C10H15N3O5
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (195.11 mM; Ultrasonic )
SMILES

Nc1nc(=O)n(cc1CO)[C@H]1C[C@H](O)[C@@H](CO)O1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Ewelina Zarakowska, et al. Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice. J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1003-1009.?

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