Cart
sales@molnova.com
Home - Products - Others - Other Targets - AS-85

AS-85

CAS No. 2323623-80-7

AS-85( —— )

Catalog No. M35164 CAS No. 2323623-80-7

AS-85, a potent inhibitor of ASH1L histone methyltransferase (IC50 = 0.6 μM), exhibits anti-leukemic activity by strongly binding to the ASH1L SET domain (Kd = 0.78 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 211 Get Quote
5MG 392 Get Quote
10MG 655 Get Quote
25MG 1371 Get Quote
50MG 2190 Get Quote
100MG 3411 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    AS-85
  • Note
    Research use only, not for human use.
  • Brief Description
    AS-85, a potent inhibitor of ASH1L histone methyltransferase (IC50 = 0.6 μM), exhibits anti-leukemic activity by strongly binding to the ASH1L SET domain (Kd = 0.78 μM).
  • Description
    AS-85 is a potent ASH1L histone methyltransferase inhibitor (IC50=0.6 μM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the Kd value of 0.78 μM.
  • In Vitro
    AS-85 inhibits the growth of leukemia cells (MV4;11, MOLM13, and KOPN8) harboring different MLL1 translocations, with GI50 values ranging from 5?μM to 25?μM, and demonstrates no effect in K562 leukemia cells without MLL1 translocations.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2323623-80-7
  • Formula Weight
    579.66
  • Molecular Formula
    C26H28F3N5O3S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (172.51 mM; Ultrasonic )
  • SMILES
    NC(=S)c1cccc(c1)-c1cn(C2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(CNC(=O)C3CNC3)ccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. David S. Rogawski, Jing Deng, Hao Li, Tomasz Cierpicki, Jolanta Grembecka, et al. Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun. 2021 May 14;12(1):2792.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • (His(1-Me)2)-TRH

    (His(1-Me)2)-TRH

  • CALP1

    Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-1 gp120-activated channels, inhibiting Ca2+-mediated cytotoxicity and apoptosis (IC50 = 52 μM). Shown to protect pancreatic acinar cells from gossypol induced necrosis. Inhibits VLA-5-mediated adhesion of mast cells to fibronectin in vitro and attenuates inflammatory cell influx in guinea pig lung in vivo.

  • α-Curcumene

    α-curcumene (compound 12) is isolated from the essential oil of rhizomes of Curcuma aromatica and can be synthesized artificially.

Sign In Join Free