YNT-185( —— )

Catalog No. M35102 CAS No. 1804978-81-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

YNT-185
Note

Research use only, not for human use.
Brief Description

YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), with EC50 values of 0.028 μM for OX2R and 2.75 μM for OX1R.
Description

YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models.
In Vitro

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In Vivo

YNT-185 (20-40 mg/kg; i.p.) increases wakefulness in mice.YNT-185 (300 nmol; i.c.v.) significantly increases wake time for 3 hours in a dose-dependent manner, accompanied by a decrease in NREM sleep time, in wild-type mice but not in OXRDKO mice.Animal Model:Male wild-type C57BL/6J mice Dosage:20, 40 mg/kg Administration:I.p.Result:Wake time was also significantly increased.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

OX Receptor
Research Area

——
Indication

——

CAS Number

1804978-81-1
Formula Weight

615.74
Molecular Formula

C33H37N5O5S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (162.41 mM; Ultrasonic )
SMILES

S(NC1=CC(NCCNC(=O)C2=C(N(C)C)C=CC=C2)=CC=C1)(=O)(=O)C3=C(OC)C=CC(=C3)C4=CC(C(N(C)C)=O)=CC=C4
Chemical Name

——

1. Nagahara T, et al. Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists. J Med Chem. 2015;58(20):7931-7937.?

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