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FSCPX
CAS No. 156547-56-7
FSCPX( —— )
Catalog No. M35087 CAS No. 156547-56-7
FSCPX is a potent and selective irreversible antagonist of the A1 adenosine receptor (A1AR), exhibiting low nanomolar binding potency.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 79 | In Stock |
|
| 5MG | 191 | In Stock |
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| 10MG | 287 | In Stock |
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| 25MG | 486 | In Stock |
|
| 50MG | 637 | In Stock |
|
| 100MG | 853 | In Stock |
|
| 200MG | 1144 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameFSCPX
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NoteResearch use only, not for human use.
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Brief DescriptionFSCPX is a potent and selective irreversible antagonist of the A1 adenosine receptor (A1AR), exhibiting low nanomolar binding potency.
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DescriptionFSCPX is a potent and selective irreversible antagonist of A1 adenosine receptor (A1AR), with low nanomolar potency for binding to the A1AR. FSCPX could modify the effect of NBTI, a nucleoside transport inhibitor, by reducing the interstitial adenosine level in the guinea pig atrium.
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In VitroFSCPX irreversibly blocks the binding of [3H]-8-cyclopentyl-1,3dipropylxanthine ([3H]DPCPX), with an IC50 of 11.8±3.2 nM in DDT1 MF2 cells.FSCPX (20 μM; 48 h) attenuates protection from necrosis and apoptosis in A1AR-overexpressing LLC-PK1 cells.FSCPX (2-20 μM; 48 h) reverses the upregulation of HSP27 mRNA and protein in A1AR-overexpressing LLC-PK1 cells without an effect on the mRNA or protein for HSP70.
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetAdenosine Receptor
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RecptorAdenosine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number156547-56-7
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Formula Weight506.55
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Molecular FormulaC23H27FN4O6S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (98.71 mM; Ultrasonic (<60°C)
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SMILESCCCn1c(=O)n(CCCOC(=O)c2ccc(cc2)S(F)(=O)=O)c2[nH]c(nc2c1=O)C1CCCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Beauglehole AR, et, al. New irreversible adenosine A(1) antagonists based on FSCPX. Bioorg Med Chem Lett. 2002 Nov 4; 12(21): 3179-82.?
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