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HBDDE
CAS No. 154675-18-0
HBDDE( —— )
Catalog No. M35086 CAS No. 154675-18-0
HBDDE is a selective model inhibitor of the isoenzymes PKCα and PKCγ with IC 50 s of 43 μM and 50 μM, respectively.HBDDE has a higher affinity for PKCα/PKCγ than the PKCδ, PKCβI, and PKCβII isoenzymes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 692 | In Stock |
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| 10MG | 943 | In Stock |
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| 25MG | 1397 | In Stock |
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| 50MG | 1841 | In Stock |
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| 100MG | 2325 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameHBDDE
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NoteResearch use only, not for human use.
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Brief DescriptionHBDDE is a selective model inhibitor of the isoenzymes PKCα and PKCγ with IC 50 s of 43 μM and 50 μM, respectively.HBDDE has a higher affinity for PKCα/PKCγ than the PKCδ, PKCβI, and PKCβII isoenzymes.
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DescriptionHBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis.
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In VitroHBDDE (50 μM; 5 hours) treatment reduces cell viability significantly by ~70%. HBDDE exhibits a marked increase in caspase-3 activity..Cell Viability Assay Cell Line:Cerebellar granule cells Concentration:50 μM Incubation Time:5 hours Result:Reduced cell viability significantly by ~70%.
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis | PKC
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Research Area——
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Indication——
Chemical Information
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CAS Number154675-18-0
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Formula Weight338.31
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Molecular FormulaC16H18O8
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Purity>98% (HPLC)
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Solubility——
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SMILESC(OC)C1=C(C(O)=C(O)C(O)=C1)C2=C(COC)C=C(O)C(O)=C2O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. A Mathur, et al. 2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether (HBDDE)-induced neuronal apoptosis independent of classical protein kinase C alpha or gamma inhibition. Biochem Pharmacol. 2000 Sep 15;60(6):809-15.?
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