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CSN5i-3 B
CAS No. 2375740-98-8
CSN5i-3 B( —— )
Catalog No. M32870 CAS No. 2375740-98-8
CSN5i-3 is a potent, selective, and orally available inhibitor of the proteolytic subunit of the CSN complex, CSN5.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 842 | In Stock |
|
| 5MG | 772 | In Stock |
|
| 10MG | 1169 | In Stock |
|
| 25MG | 1739 | In Stock |
|
| 50MG | 2297 | In Stock |
|
| 100MG | 3097 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCSN5i-3 B
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NoteResearch use only, not for human use.
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Brief DescriptionCSN5i-3 is a potent, selective, and orally available inhibitor of the proteolytic subunit of the CSN complex, CSN5.
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DescriptionCSN5i-3 is a potent, selective and orally available inhibitor of CSN5/Jab1, and inhibits CSN-catalysed Cul1 deneddylation with an IC50 value of 5.8 nM.
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In VitroCSN5i-3 traps CRLs in the neddylated state, which leads to inactivation of a subset of CRLs by inducing degradation of their substrate recognition module.
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In VivoCSN5i-3 shows a good pharmacokinetic profile. Treatment with CSN5i-3 triggers the formation of cleaved PARP and cleaved caspase 3 indicative of apoptosis induction.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number2375740-98-8
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Formula Weight505.56
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Molecular FormulaC28H29F2N5O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 100 mg/mL (197.80 mM)
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SMILESCC(C)n1nc(cc1C(=O)Nc1ccc([C@H]2[C@@H](O)CCCc3cncn23)c(c1)-c1ccccc1)C(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Schlierf A, et al. Targeted inhibition of the COP9 signalosome for treatment of cancer. Nat Commun. 2016 Oct 24;7:13166.?
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