Azide-PEG3-Desthiobiotin

Research use only, not for human use.

Azide-PEG3-Desthiobiotin is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.

Azide-PEG3-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG3-Desthiobiotin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

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Others

Other Targets

Others

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1426828-06-9

414.5

C18H34N6O5

>98% (HPLC)

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C(CCCCC(NCCOCCOCCOCCN=[N+]=[N-])=O)[C@@H]1[C@H](C)NC(=O)N1

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(-20℃)

With Ice Pack

≥ 2 years