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CAY10640

CAS No. 1208549-68-1

CAY10640( —— )

Catalog No. M35030 CAS No. 1208549-68-1

CAY10640 (sEH inhibitor-1) is a potent, orally active, water-soluble epoxide hydrolase (sEH) inhibitor that inhibits sEH in humans and mice with IC50s of 0.4 and 5.3 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CAY10640
  • Note
    Research use only, not for human use.
  • Brief Description
    CAY10640 (sEH inhibitor-1) is a potent, orally active, water-soluble epoxide hydrolase (sEH) inhibitor that inhibits sEH in humans and mice with IC50s of 0.4 and 5.3 nM, respectively.
  • Description
    sEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC50s of 0.4 and 5.3 nM in human and murine, respectively.
  • In Vitro
    ——
  • In Vivo
    Pharmacokinetic parameters of sEH inhibitor-1 (TCPU) after oral gavage with a non-compartmental analysis.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Epoxide Hydrolase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1208549-68-1
  • Formula Weight
    371.35
  • Molecular Formula
    C17H20F3N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (336.61 mM; Ultrasonic )
  • SMILES
    C(=O)(C1CC1)N2CCC(NC(NC3=CC=C(OC(F)(F)F)C=C3)=O)CC2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Liu JY, et al. Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models. Eur J Pharm Sci. 2013;48(4-5):619-627. ?
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