LEI-401( —— )

Catalog No. M34998 CAS No. 2393840-15-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

LEI-401
Note

Research use only, not for human use.
Brief Description

LEI-401 is a selective and potent NAPE-PLD inhibitor that crosses the blood-brain barrier (IC50: 27 nM).LEI-401 reduces the level of n-acylethanolamines (NAEs) in the brain of free-ranging mice and modulates their emotional behaviour.
Description

LEI-401 is a first-in-class, selective, and CNS-active NAPE-PLD (N-acylphosphatidylethanolamine phospholipase D) inhibitor, with an IC50 of 27 nM. LEI-401 modulates emotional behavior in mice.
In Vitro

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In Vivo

Animal Model:Male 7–12-week-old C57BL/6J mice Dosage:30?mg/kg Administration:I.p.Result:Produced a significant increase in freezing as compared to vehicle.Animal Model:C57BL/6J mice Dosage:10 mg/kg Administration:P.o. (Pharmacokinetic Analysis) Result:The t1/2, Cmax, tmax, AUClast, and F values were 2.5 hours, 1370 ng/mL, 2 hours, 6760 h*ng/mL, and 25%, respectively.
Synonyms

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Pathway

Metabolic Enzyme/Protease
Target

Phospholipase
Recptor

Phospholipase
Research Area

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Indication

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1. Mock ED, et al. Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice. Nat Chem Biol. 2020;16(6):667-675.?

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