Amifostine thiol

Research use only, not for human use.

Amifostine thiol (WR-1065) is a radioprotectant that protects DNA from fast neutron-induced strand breaks.

Amifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine (HY-B0639). Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway.

Amifostine thiol can reduce both the direct and delayed detrimental effects of both high and low-LET radiation exposures.Amifostine thiol attenuates both the DNA damage and the G1-phase arrest induced by radiation. Amifostine thiol (4 mM; 30 minutes) protects RKO36 cells from chromosomal damage and death induced by ionizing radiation.Amifostine thiol (4 mM; 30 minutes) protects irradiated RKO36 cells from delayed genomic instability.Amifostine thiol is cytotoxic to RKO36 cells at milimolar concentrations, especially after continuous treatment.Amifostine thiol at 40 μM protects RKO36 cells from delayed genomic instability but not from cell death and immediate chromosomal damage.Amifostine thiol activates JNK resulting in the phosphorylation of p53 at threonine 81.Amifostine thiol affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells.

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Apoptosis

MDM2-p53

Mdm2 | p53

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31098-42-7

134.24

C5H14N2S

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (1862.34 mM; Ultrasonic ) H2O : 100 mg/mL (744.93 mM; Ultrasonic)

NCCCNCCS

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(-20℃)

With Ice Pack

≥ 2 years