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TRPV3 antagonist 74a
CAS No. 1432051-63-2
TRPV3 antagonist 74a( —— )
Catalog No. M34945 CAS No. 1432051-63-2
TRPV3 antagonist 74a (TRPV3 74a) is a specific TRPV3 antagonist for the study of neurological disorders.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameTRPV3 antagonist 74a
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NoteResearch use only, not for human use.
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Brief DescriptionTRPV3 antagonist 74a (TRPV3 74a) is a specific TRPV3 antagonist for the study of neurological disorders.
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DescriptionTRPV3 antagonist 74a is a potent and selective TRPV3 antagonist. TRPV3 antagonist 74a displays no significant activity against a panel of other ion channels. TRPV3 antagonist 74a can be used for the research of neuropathic pain.
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In VitroTRPV3 antagonist 74a (100 μΜ; 2300 seconds; keratinocytes) largely attenuates SLIGRL or SLIGKV-induced Ca2+ responses.
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In VivoTRPV3 antagonist 74a (150 μg; intradermal injection; 30 minutes) decreases the number of scratches significantly..TRPV3 antagonist 74a (10~100 mg/kg; p.o.) dose-dependently attenuates mechanical allodynia induced by von Frey hair stimulation to the ipsilateral (injured) hind paw. TRPV3 antagonist 74a exhibits anti-nociceptive activity in the reserpine model of central pain by increasing muscle pressure threshold.Animal Model:WT mice Dosage:150 μg Administration:Intradermal injection; 30 minutes Result:The number of scratches decreased significantly.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorTRP/TRPV Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number1432051-63-2
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Formula Weight338.32
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Molecular FormulaC17H17F3N2O2
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Purity>98% (HPLC)
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Solubility——
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SMILES[C@H](O)([C@]1(C[C@@](C)(O)C1)C2=CC(C(F)(F)F)=CC=N2)C3=CC=CC=N3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gomtsyan A, et al. Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists. J Med Chem. 2016;59(10):4926-4947.?
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