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CB2R PAM
CAS No. 2244579-87-9
CB2R PAM( —— )
Catalog No. M34909 CAS No. 2244579-87-9
CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors without affecting receptor activity in the absence of agonists.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 116 | In Stock |
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| 10MG | 170 | In Stock |
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| 25MG | 280 | In Stock |
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| 50MG | 417 | In Stock |
|
| 100MG | 613 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 1283 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCB2R PAM
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NoteResearch use only, not for human use.
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Brief DescriptionCB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors without affecting receptor activity in the absence of agonists.
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DescriptionCB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain.
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In VitroCB2R PAM (100 nM) significantly enhances the ability of CP55940 and 2-AG, but not of AEA, to stimulate [35S]GTPγS binding to CB2Rs.
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In VivoCB2R PAM (1-20 mg/kg; p.o.) displays antinociceptive activity.Animal Model:Male CD-1 albino mice (Oxaliplatin-induced neuropathic pain model) Dosage:1, 5, 10, 20 mg/kg Administration:P.o.Result:Significantly increased licking latency in the animals starting from 5 mg/kg.
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Synonyms——
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PathwayGPCR/G Protein
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TargetCannabinoid Receptor
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RecptorCannabinoid Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number2244579-87-9
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Formula Weight435.33
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Molecular FormulaC21H24BrFN2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (114.86 mM; Ultrasonic )
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SMILESN(C(=O)C1CCCCCC1)C=2C(=O)N(CC3=CC=C(F)C=C3)C=C(Br)C2C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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CB2R/FAAH modulator-...
CB2R/FAAH modulator-3 (compound 27) is a modulator targeting CB2R and FAAH, acting as a CB2R agonist with a Ki value of 20.1 nM and a CB1R agonist with a Ki value of 67.6 nM, while inhibiting FAAH with an IC50 value of 3.4 μM.
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Hemopressin (human, ...
Bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity in vivo.
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Hemopressin (rat)
Bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity and induces hypophagia in vivo.
