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CB2R PAM
CAS No. 2244579-87-9
CB2R PAM( —— )
Catalog No. M34909 CAS No. 2244579-87-9
CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors without affecting receptor activity in the absence of agonists.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 116 | In Stock |
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| 10MG | 170 | In Stock |
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| 25MG | 280 | In Stock |
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| 50MG | 417 | In Stock |
|
| 100MG | 613 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1283 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCB2R PAM
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NoteResearch use only, not for human use.
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Brief DescriptionCB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors without affecting receptor activity in the absence of agonists.
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DescriptionCB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain.
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In VitroCB2R PAM (100 nM) significantly enhances the ability of CP55940 and 2-AG, but not of AEA, to stimulate [35S]GTPγS binding to CB2Rs.
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In VivoCB2R PAM (1-20 mg/kg; p.o.) displays antinociceptive activity.Animal Model:Male CD-1 albino mice (Oxaliplatin-induced neuropathic pain model) Dosage:1, 5, 10, 20 mg/kg Administration:P.o.Result:Significantly increased licking latency in the animals starting from 5 mg/kg.
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Synonyms——
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PathwayGPCR/G Protein
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TargetCannabinoid Receptor
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RecptorCannabinoid Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number2244579-87-9
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Formula Weight435.33
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Molecular FormulaC21H24BrFN2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (114.86 mM; Ultrasonic )
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SMILESN(C(=O)C1CCCCCC1)C=2C(=O)N(CC3=CC=C(F)C=C3)C=C(Br)C2C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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A-836339
A-836339 (A836339) is a potent and selective cannabinoid CB2 receptor agonist with Ki of 0.64 and 0.76 nM for human and rat CB2 receptors.
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Tetrahydrocannabivar...
Tetrahydrocannabivarin is a neutral cannabis receptor subtype (CB1) receptor antagonist, it can increases neural responding to rewarding and aversive stimuli, this effect profile suggests therapeutic activity in obesity, perhaps with a lowered risk of depressive side effects. Tetrahydrocannabivarin exhibits anticonvulsant effects in a piriform cortical brain slice model of epileptiform activity.
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SCH-336
SCH-336 is a CB2 receptor agonist (Ki-1.8 nM, EC50-2 nM) with effective, selective, and oral activity. SCH-336 is also bioactive against CB1 receptor, and is 100 times more selective to CB2 receptor than CB1.
