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Ac-YVAD-CMK
CAS No. 178603-78-6
Ac-YVAD-CMK( —— )
Catalog No. M34832 CAS No. 178603-78-6
Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 217 | In Stock |
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| 10MG | 353 | In Stock |
|
| 25MG | 582 | In Stock |
|
| 50MG | 808 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAc-YVAD-CMK
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NoteResearch use only, not for human use.
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Brief DescriptionAc-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.
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DescriptionAc-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetIL Receptor
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RecptorIL Receptor | Caspase | Immunology/Inflammation related | Pyroptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number178603-78-6
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Formula Weight540.99
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Molecular FormulaC24H33ClN4O8
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (184.85 mM; Ultrasonic )
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SMILESCC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)CCl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang F, et al. Alcohol accumulation promotes esophagitis via pyroptosis activation. Int J Biol Sci. 2018;14(10):1245-1255. Published 2018 Jul 13. ?
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