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Cysmethynil
CAS No. 851636-83-4
Cysmethynil( —— )
Catalog No. M34818 CAS No. 851636-83-4
Cysmethynil is an indole-based time-dependent inhibitor of Icmt with antitumour activity and inhibitory effects on RAS membrane-binding and EGF signalling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 52 | In Stock |
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| 5MG | 85 | In Stock |
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| 10MG | 136 | In Stock |
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| 25MG | 275 | In Stock |
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| 50MG | 431 | In Stock |
|
| 100MG | 693 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 1386 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCysmethynil
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NoteResearch use only, not for human use.
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Brief DescriptionCysmethynil is an indole-based time-dependent inhibitor of Icmt with antitumour activity and inhibitory effects on RAS membrane-binding and EGF signalling.
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DescriptionCysmethynil is an Icmt inhibitor(IC50 = 2.4 μM). Cysmethynil inhibites RAS membrane binding and EGF signal transduction. Cysmethynil prevents the cells in the G1 phase and induces autophagy. Cysmethynil inhibits PC3 cells proliferation, has synergistic effect with Paclitaxel (HY-B0015) and Doxorubicin (HY-15142A). Cysmethynil has anti-tumor effects and can be used for solid tumor (such as prostate cancer et al.) research.
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In VitroCell Viability AssayCell Line:PC3 cells Concentration:20-30 μM cysmethynil Incubation Time:1-6 days Result:Resulted in a dose- and time-dependent reduction in the number of viable PC3 cells.
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In VivoAnimal Model:6 week-old SCID mice with SiHa cells in the mice flank Dosage:20 mg/kg (single; combination with Paclitaxel or Doxorubicin)Administration:intraperitoneal injection; three times a week; 2 weeks Result: Decreased in tumor size when treated with Cys alone, or Cysmethynil+Paclitaxel(HY-B0015)/Cysmethynil+ Doxorubicin(HY-15142A) .Animal Model:SCID mice with PC3 cells in a xenograft model Dosage:0.1 mg/g or 0.2 mg/g Cysmethynil Administration:intraperitoneal injection; every 48 h; 28 days Result:Decreased in tumor size when treated with both doses of cysmethynil.
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Synonyms——
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy | Ras
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Research Area——
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Indication——
Chemical Information
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CAS Number851636-83-4
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Formula Weight376.53
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Molecular FormulaC25H32N2O
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N)CC1=CN(C2=CC=C(C=C21)C=3C=CC=C(C3)C)CCCCCCCC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Winter-Vann AM, et al. A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4336-41.?
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