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Oxyphenisatin acetate

CAS No. 115-33-3

Oxyphenisatin acetate( —— )

Catalog No. M20707 CAS No. 115-33-3

Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7 T47D HS578T and MDA-MB-468.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Oxyphenisatin acetate
  • Note
    Research use only, not for human use.
  • Brief Description
    Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7 T47D HS578T and MDA-MB-468.
  • Description
    Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7 T47D HS578T and MDA-MB-468.
  • In Vitro
    Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468. In the estrogen receptor (ER) positive MCF7 and T47D cells, oxyphenisatin acetate induces TNFα expression and TNFR1 degradation, indicating autocrine receptor-mediated apoptosis in these lines. Ten micromoles per liter Oxyphenisatin acetate treatment results in autophagy and mitochondrial dysfunction.
  • In Vivo
    Oxyphenisatin acetate (300 mg/kg, i.p.) delivers intraperitoneally inhibited tumor growth, accompanied by phosphorylation of eIF2α and degradation of TNFR1 in an MCF7 xenograft model.
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Autophagy
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    115-33-3
  • Formula Weight
    401.41
  • Molecular Formula
    C24H19NO5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:150 mg/mL (373.68 mM)
  • SMILES
    CC(=O)Oc1ccc(cc1)C1(C(=O)Nc2ccccc12)c1ccc(OC(C)=O)cc1
  • Chemical Name
    2-Indolinone 33-bis(p-hydroxyphenyl)- diacetate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Morrison B L Mullendore M E Stockwin L H et al. Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy mitochondrial dysfunction and autocrine TNFα-mediated apoptosis[J]. Cancer Medicine 2013:n/a-n/a.
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