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N-Desmethyl Sildenafil
CAS No. 139755-82-1
N-Desmethyl Sildenafil( —— )
Catalog No. M34815 CAS No. 139755-82-1
N-Desmethyl Sildenafil is the major metabolite of Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 44 | In Stock |
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| 10MG | 71 | In Stock |
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| 25MG | 145 | In Stock |
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| 50MG | 228 | In Stock |
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| 100MG | 332 | In Stock |
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| 200MG | 492 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameN-Desmethyl Sildenafil
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NoteResearch use only, not for human use.
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Brief DescriptionN-Desmethyl Sildenafil is the major metabolite of Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor.
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DescriptionN-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor.
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In VitroN-Desmethyl Sildenafil increases the amplitude of electroretinogram (ERG) recorded from the dark-adapted isolated rat retina, most probably through the enhancement of the photoreceptor cell response. The formation of N-Desmethyl Sildenafil is examined using CYP3A supersomes co-expressing human P450 oxidoreductase and cytochrome b5. N-Desmethyl Sildenafil is catalyzed by CYP3A4, CYP3A5, and to a lesser extent by CYP3A7.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorDrug Metabolite
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Research Area——
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Indication——
Chemical Information
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CAS Number139755-82-1
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Formula Weight460.55
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Molecular FormulaC21H28N6O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (542.83 mM; Ultrasonic )
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SMILESCCCc1nn(C)c2c1[nH]c(nc2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCNCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Péter Barabás, et al. Sildenafil, N-desmethyl-sildenafil and Zaprinast enhance photoreceptor response in the isolated rat retina. Neurochem Int. 2003 Nov;43(6):591-5.?
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