Cart
sales@molnova.com
Soraprazan
CAS No. 261944-46-1
Soraprazan( —— )
Catalog No. M33128 CAS No. 261944-46-1
Soraprazan is a reversible, and fast-acting gastric H+/K+ ATPase inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 341 | In Stock |
|
| 2MG | 224 | In Stock |
|
| 5MG | 424 | In Stock |
|
| 10MG | 708 | In Stock |
|
| 25MG | 1093 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSoraprazan
-
NoteResearch use only, not for human use.
-
Brief DescriptionSoraprazan is a reversible, and fast-acting gastric H+/K+ ATPase inhibitor.
-
DescriptionSoraprazan (BYK61359) is a selective, reversible K-competitive inhibitor of the H,K-ATPase (Ki=6.4 nM), with an IC50 of 0.19 μM in gastric glands. Soraprazan binds to the H,K-ATPase with a Kd of 28.27 nM.Soraprazan shows immediate inhibition of acid secretion and is more than 2000-fold selective for H,K-ATPase over Na,K- and Ca-ATPases.
-
In VitroSoraprazan (BYK61359) is a potent inhibitor of gastric H,K-ATPase, with an IC50 of 0.1 μM when measured in ion-leaky vesicles in the presence of 1 mM potassium. Soraprazan (BYK61359) also effectively inhibits dibutyryl cAMP-stimulated [14C]AP accumulation in isolated gastric glands with an IC50 of 0.19 μM (0.09-0.40 μM geometric mean from n=6 with 95% confidence limits).
-
In VivoSoraprazan (1-27 μmol/kg; p.o.) shows rapid and consistent inhibition of acid secretion in dog .
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorOthers
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number261944-46-1
-
Formula Weight367.44
-
Molecular FormulaC21H25N3O3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 200 mg/mL (544.31 mM; Ultrasonic )
-
SMILESCOCCO[C@H]1[C@H](O)[C@H](Nc2c1ccn1c(C)c(C)nc21)c1ccccc1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Simon WA, et al. Soraprazan: setting new standards in inhibition of gastric acid secretion. J Pharmacol Exp Ther. 2007 Jun;321(3):866-74. Epub 2007 Mar 16.?
molnova catalog
related products
-
Secretin Acetate, po...
Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism.
-
HPV-E6-M
HPV-E6-M
-
13-Diaminopropane
13-Diaminopropane is a common synthesis reagent used in the synthesis of cholinesterase inhibitors and thrombosis inhibitors.
