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Lipoxin A4
CAS No. 89663-86-5
Lipoxin A4( —— )
Catalog No. M34814 CAS No. 89663-86-5
Lipoxin A4 (LXA4) is a lipoxygenase-derived arachidonate-like mediator with anti-inflammatory properties.Lipoxin A4 attenuates MSU crystal-induced NLRP3 inflammasome activation through inhibition of Nrf2, and regulates M1/M2 macrophage polarization through the FPR2-IRF pathway.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product NameLipoxin A4
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NoteResearch use only, not for human use.
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Brief DescriptionLipoxin A4 (LXA4) is a lipoxygenase-derived arachidonate-like mediator with anti-inflammatory properties.Lipoxin A4 attenuates MSU crystal-induced NLRP3 inflammasome activation through inhibition of Nrf2, and regulates M1/M2 macrophage polarization through the FPR2-IRF pathway.
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DescriptionLipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM.
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In VitroLipoxin A4 (LXA4) inhibits the expression of IL-6 and IL-8 in NHEKs. Lipoxin A4 downregulates the expression of cyclin D1.Lipoxin A4 also suppresses the ERK1/2 phosphorylation and NF-kB-p65 nuclear translocation of NHEKs.LXA4 (100 nM; preincubation for 30 minutes)inhibits the proliferation of NHEKs with or without stimulating by LPS (10 μg/mL). LXA4 pretreatment (100? nM for 30?minutes) downregulates the LPS-induced secretion and expression of HMGB1 in keratinocytes.Cell Proliferation Assay Cell Line:Normal human epidermal keratinocytes (NHEKs) Concentration:100 nM Incubation Time:30 minutes Result:A significant increase in proliferation of NHEKs after 7 days of stimulation with LPS (10 μg/mL) was seen. However, there was a significant decrease in the proliferation of NHEKs when pretreated with LXA4 for 30 min. Western Blot Analysis Cell Line:Normal human epidermal keratinocytes (NHEKs) Concentration:100?nM Incubation Time:30?minutes.Result:HMGB1 protein levels in the cytoplasm of NHEKs were induced by LPS, which were decreased after preincubation with LXA4 but decreased in the nucleus after stimulation with LPS.
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetEndogenous Metabolite
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RecptorEndogenous Metabolite | Interleukin
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Research Area——
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Indication——
Chemical Information
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CAS Number89663-86-5
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Formula Weight352.47
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Molecular FormulaC20H32O5
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Purity>98% (HPLC)
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Solubility——
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SMILES[C@H]([C@H](CCCC(O)=O)O)(/C=C/C=C/C=C\C=C\[C@H](CCCCC)O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Feng Hu, et al. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes associated with the ERK1/2 and NF-κB pathways. J Dermatol Sci. 2015 Jun;78(3):181-8.?
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