VRK-IN-1( —— )

Catalog No. M34797 CAS No. 2378855-09-3

VRK-IN-1 is a potent and selective inhibitor of [cowpox-associated kinase 1 (VRK1)], suitable for researching neurological disorders.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	259	In Stock
5MG	237	In Stock
10MG	378	In Stock
25MG	750	In Stock
50MG	1107	In Stock
100MG	1479	In Stock
200MG	2018	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

VRK-IN-1
Note

Research use only, not for human use.
Brief Description

VRK-IN-1 is a potent and selective inhibitor of [cowpox-associated kinase 1 (VRK1)], suitable for researching neurological disorders.
Description

VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders.
In Vitro

VRK-IN-1 binds to VRK1-FL by enthalpy-driven, with a Kd of 190 nM.VRK-IN-1 (0.4-25 μM; 24 h) slightly decreases the viability of human HeLa cells at the concentration of 3.2 μM.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

2378855-09-3
Formula Weight

349.28
Molecular Formula

C18H11F4NO2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (286.30 mM; Ultrasonic )
SMILES

Cc1ncc(cc1-c1cc(F)c(O)c(F)c1)-c1cc(F)c(O)c(F)c1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Serafim RAM, et, al. Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2. ACS Med Chem Lett. 2019 Aug 19;10(9):1266-1271.?

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