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TD-165
CAS No. 2305936-56-3
TD-165( —— )
Catalog No. M27017 CAS No. 2305936-56-3
TD-165 is a PROTAC-based cereblon (CRBN) degrader comprising a CRBN ligand binding group, a linker and a VHL binding group.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 260 | Get Quote |
|
| 10MG | 430 | Get Quote |
|
| 25MG | 710 | Get Quote |
|
| 50MG | 972 | Get Quote |
|
| 100MG | 1332 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTD-165
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NoteResearch use only, not for human use.
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Brief DescriptionTD-165 is a PROTAC-based cereblon (CRBN) degrader comprising a CRBN ligand binding group, a linker and a VHL binding group.
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DescriptionTD-165 is a PROTAC-based cereblon (CRBN) degrader comprising a CRBN ligand binding group, a linker and a VHL binding group.(In Vitro):Administration of 0.1-10 μM TD-165 for 24 hours resulted in a concentration-dependent decrease in CRBN protein levels in HEK293T cells. Administration of 0-100 nM TD-165 for 24 hours showed a 50% degradation concentration (DC50) of 20.4 nM and a maximum degradation (Dmax) value of 99.6%.
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In VitroTD-165 (0-100 nM; 24 hours) shows 50% degradation concentration (DC50) and maximum degradation (Dmax) value of 20.4?nM and 99.6%, respectively.TD-165 (0.1-10?μM; 24 hours) leads to a concentration-dependent decrease in the level of CRBN proteins in HEK293T cells.Cell Viability Assay Cell Line:HEK293T cells Concentration:0-100 nM Incubation Time:24 hours Result:Exhibited an DC50 value of 20.4?nM.Western Blot Analysis Cell Line:HEK293T cells Concentration:0.1, 1, and 10?μM Incubation Time:24 hours Result:Decreased the level of CRBN protein.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorBacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number2305936-56-3
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Formula Weight870.08
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Molecular FormulaC46H59N7O8S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (57.47 mM)
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SMILESCc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCNc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)C(C)(C)C)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.XiaoyeGeng, et al. Design and fabrication of reversible thermochromic microencapsulated phase change materials for thermal energy storage and its antibacterial activity. Energy. Volume 159, 15 September 2018, Pages 857-869.
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