Cart
sales@molnova.com
Home - Products - Others - Other Targets - TD-165

TD-165

CAS No. 2305936-56-3

TD-165( —— )

Catalog No. M27017 CAS No. 2305936-56-3

TD-165 is a PROTAC-based cereblon (CRBN) degrader comprising a CRBN ligand binding group, a linker and a VHL binding group.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 338 In Stock
5MG 235 In Stock
10MG 353 In Stock
25MG 708 In Stock
50MG 1004 In Stock
100MG 1376 In Stock
200MG 1851 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    TD-165
  • Note
    Research use only, not for human use.
  • Brief Description
    TD-165 is a PROTAC-based cereblon (CRBN) degrader comprising a CRBN ligand binding group, a linker and a VHL binding group.
  • Description
    TD-165 is a PROTAC-based cereblon (CRBN) degrader comprising a CRBN ligand binding group, a linker and a VHL binding group.(In Vitro):Administration of 0.1-10 μM TD-165 for 24 hours resulted in a concentration-dependent decrease in CRBN protein levels in HEK293T cells. Administration of 0-100 nM TD-165 for 24 hours showed a 50% degradation concentration (DC50) of 20.4 nM and a maximum degradation (Dmax) value of 99.6%.
  • In Vitro
    TD-165 (0-100 nM; 24 hours) shows 50% degradation concentration (DC50) and maximum degradation (Dmax) value of 20.4?nM and 99.6%, respectively.TD-165 (0.1-10?μM; 24 hours) leads to a concentration-dependent decrease in the level of CRBN proteins in HEK293T cells.Cell Viability Assay Cell Line:HEK293T cells Concentration:0-100 nM Incubation Time:24 hours Result:Exhibited an DC50 value of 20.4?nM.Western Blot Analysis Cell Line:HEK293T cells Concentration:0.1, 1, and 10?μM Incubation Time:24 hours Result:Decreased the level of CRBN protein.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Bacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2305936-56-3
  • Formula Weight
    870.08
  • Molecular Formula
    C46H59N7O8S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (57.47 mM)
  • SMILES
    Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCNc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)C(C)(C)C)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.XiaoyeGeng, et al. Design and fabrication of reversible thermochromic microencapsulated phase change materials for thermal energy storage and its antibacterial activity. Energy. Volume 159, 15 September 2018, Pages 857-869.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Cefuroxime

    Cefuroxime (Standard) is the analytical standard of Cefuroxime. This product is intended for research and analytical applications. Cefuroxime is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime has a broad spectrum activity against Gram-positive and Gram-negative bacteria.

  • EC5026

    EC5026 has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators.?EC5026 (BPN-19186) is a first-in-class, small molecule that potently inhibits soluble Epoxide Hydrolase (sEH), a key regulatory enzyme involved in the metabolism of membrane fatty acids.?Inhibition of sEH treats pain by stabilizing natural analgesic and anti-inflammatory mediators.

  • Debrisoquin hydriodi...

    Debrisoquin hydriodide is a chemical compound.

Sign In Join Free