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Felcisetrag
CAS No. 916075-84-8
Felcisetrag( —— )
Catalog No. M34442 CAS No. 916075-84-8
Felcisetrag (TD-8954) is a potent and selective orally active 5-HT4 agonist with gastrointestinal prokinetic properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 249 | In Stock |
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| 5MG | 226 | In Stock |
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| 10MG | 335 | In Stock |
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| 25MG | 539 | In Stock |
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| 50MG | 714 | In Stock |
|
| 100MG | 958 | In Stock |
|
| 200MG | 1293 | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameFelcisetrag
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NoteResearch use only, not for human use.
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Brief DescriptionFelcisetrag (TD-8954) is a potent and selective orally active 5-HT4 agonist with gastrointestinal prokinetic properties.
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DescriptionFelcisetrag (TD-8954) is an orally active, potent and selective 5-HT4 receptor agonist with gastrointestinal prokinetic properties. Felcisetrag has high affinity (pKi =9.4) for human 5-HT4(c) receptors.
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In VitroFelcisetrag produces an elevation of cAMP in HEK-293 cells expressing the h5-HT4(c) receptor (pEC50?=?9.3), and contracts the guinea pig colonic longitudinal muscle/myenteric plexus preparation (pEC50?=?8.6). Felcisetrag has moderate intrinsic activity in the vitro assays.
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In VivoFelcisetrag (0.03~3?mg/kg; s.c.) increases the colonic transit of carmine red dye, reducing the time taken for its excretion.Felcisetrag (0.03~10?mg/kg; intraduodenal administration) evokes a dose-dependent relaxation of the esophagus.Felcisetrag (10 and 30?μg/kg; p.o) produces an increase in contractility of the antrum, duodenum, and jejunum.Animal Model:Guinea pigsDosage:0.03~3?mg/kg Administration:S.c.Result:Increased the colonic transit of carmine red dye, reducing the time taken for its excretion.Animal Model:Rats Dosage:0.03~10?mg/kg Administration:Intraduodenal administration Result:Evoked a dose-dependent relaxation of the esophagus.Animal Model:Dogs Dosage:10 and 30?μg/kg Administration:P.o Result:Produced an increase in contractility of the antrum, duodenum, and jejunum.
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Synonyms——
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PathwayGPCR/G Protein
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number916075-84-8
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Formula Weight455.59
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Molecular FormulaC25H37N5O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (109.75 mM; Ultrasonic (<60°C)
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SMILESCOC(=O)N1CCC(CN2CCC(CNC(=O)c3cccc4nc([nH]c34)C(C)C)CC2)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Beattie DT, et al. The Pharmacology of TD-8954, a Potent and Selective 5-HT(4) Receptor Agonist with Gastrointestinal Prokinetic Properties. Front Pharmacol. 2011;2:25.?
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