AVN-101( AVN101 )

Catalog No. M10121 CAS No. 1025725-91-0

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Product Name

AVN-101
Note

Research use only, not for human use.
Brief Description

A higly potent, orally bioavailable, BBB permeable 5-HT7 receptor antagonist with Ki of 153 pM, with slightly lesser potency toward 5-HT6, 5-HT2A and 5HT-2C (Ki = 1.2-2.0 nM).
Description

A higly potent, orally bioavailable, BBB permeable 5-HT7 receptor antagonist with Ki of 153 pM, with slightly lesser potency toward 5-HT6, 5-HT2A and 5HT-2C (Ki = 1.2-2.0 nM); also exhibits a rather high affinity toward histamine H1 (Ki = 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki = 0.41-3.6 nM) receptors; demonstrates reasonable anxiolytic and anti-depressive activities in animal models of CNS diseases with low safety concerns.Anxiety Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

AVN101
Pathway

GPCR/G Protein
Target

5-HT Receptor
Recptor

5-HT Receptor
Research Area

Neurological Disease
Indication

Anxiety

CAS Number

1025725-91-0
Formula Weight

304.437
Molecular Formula

C21H24N2
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CC=CC=C4
Chemical Name

2,8-dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

1. Ivachtchenko AV, et al. J Alzheimers Dis. 2016 May 25;53(2):583-620.

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