Cart
sales@molnova.com
AVN-101
CAS No. 1025725-91-0
AVN-101( AVN101 )
Catalog No. M10121 CAS No. 1025725-91-0
A higly potent, orally bioavailable, BBB permeable 5-HT7 receptor antagonist with Ki of 153 pM, with slightly lesser potency toward 5-HT6, 5-HT2A and 5HT-2C (Ki = 1.2-2.0 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameAVN-101
-
NoteResearch use only, not for human use.
-
Brief DescriptionA higly potent, orally bioavailable, BBB permeable 5-HT7 receptor antagonist with Ki of 153 pM, with slightly lesser potency toward 5-HT6, 5-HT2A and 5HT-2C (Ki = 1.2-2.0 nM).
-
DescriptionA higly potent, orally bioavailable, BBB permeable 5-HT7 receptor antagonist with Ki of 153 pM, with slightly lesser potency toward 5-HT6, 5-HT2A and 5HT-2C (Ki = 1.2-2.0 nM); also exhibits a rather high affinity toward histamine H1 (Ki = 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki = 0.41-3.6 nM) receptors; demonstrates reasonable anxiolytic and anti-depressive activities in animal models of CNS diseases with low safety concerns.Anxiety Phase 2 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsAVN101
-
PathwayGPCR/G Protein
-
Target5-HT Receptor
-
Recptor5-HT Receptor
-
Research AreaNeurological Disease
-
IndicationAnxiety
Chemical Information
-
CAS Number1025725-91-0
-
Formula Weight304.437
-
Molecular FormulaC21H24N2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CC=CC=C4
-
Chemical Name2,8-dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ivachtchenko AV, et al. J Alzheimers Dis. 2016 May 25;53(2):583-620.
molnova catalog
related products
-
LY 344864 racemate
LY 344864 (racemate) is an agonist of the 5-HT1F receptor.
-
Liafensine
Liafensine(BMS-820836) is a novel and selective triple monoamine reuptake inhibitor with inhibitory effects on the reuptake of serotonin, norepinephrine, and dopamine for the study of major depressive disorder and central nervous system disorders.
-
N-Desmethyl Pimavans...
N-Desmethyl Pimavanserin (AC-279) is the active metabolite of Pimavanserin, a 5-HT2A receptor inverse agonist, which is used in the treatment of sleep disorders such as insomnia.
