Cart
sales@molnova.com
NSC49652
CAS No. 908563-68-8
NSC49652( —— )
Catalog No. M34352 CAS No. 908563-68-8
NSC49652 triggers apoptotic cell death dependent on p75NTR and JNK activity in neurons and melanoma cells, and inhibits tumor growth in a melanoma mouse model.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 75 | In Stock |
|
| 5MG | 68 | In Stock |
|
| 10MG | 116 | In Stock |
|
| 25MG | 235 | In Stock |
|
| 50MG | 365 | In Stock |
|
| 100MG | 548 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1190 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameNSC49652
-
NoteResearch use only, not for human use.
-
Brief DescriptionNSC49652 triggers apoptotic cell death dependent on p75NTR and JNK activity in neurons and melanoma cells, and inhibits tumor growth in a melanoma mouse model.
-
DescriptionNSC49652 is a reversible, orally active p75 neurotrophin receptor (p75NTR, also known as NGFR, TNFRSF16, and CD271) agonist. NSC49652 targets the transmembrane domain of p75NTR. NSC49652 induces apoptosis and affects the viability of melanoma cells.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorApoptosis
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number908563-68-8
-
Formula Weight225.24
-
Molecular FormulaC14H11NO2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : ≥ 20.83 mg/mL (92.48 mM; )
-
SMILESOc1ccccc1C(=O)\C=C\c1cccnc1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Goh ETH, et al. A Small Molecule Targeting the Transmembrane Domain of Death Receptor p75NTR Induces Melanoma Cell Death and Reduces Tumor Growth. Cell Chem Biol. 2018 Dec 20;25(12):1485-1494.e5.?
molnova catalog
related products
-
Methylisoindigotin
Meisoindigo(Natura-α; N-Methylisoindigotin; Dian III), a derivative of Indigo naturalis, might induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML).
-
SMIP004
SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.
-
(R)-CR8 trihydrochlo...
(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor that acts as a molecular glue degrader with neuroprotective activity and induces apoptosis.
