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ACBI1
CAS No. 2375564-55-7
ACBI1( —— )
Catalog No. M24091 CAS No. 2375564-55-7
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 225 | In Stock |
|
| 10MG | 363 | In Stock |
|
| 25MG | 607 | In Stock |
|
| 50MG | 849 | In Stock |
|
| 100MG | 1144 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameACBI1
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NoteResearch use only, not for human use.
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Brief DescriptionACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively.
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DescriptionACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.
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In VitroACBI1 (1-10000 nM； 3-7 days) shows anti-proliferative activity.ACBI1 (0.3 μM; 100 h) induces apoptosis in SK-MEL-5 cells.ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase von Hippel-Lindau. Cell Proliferation Assay Cell Line:MV-4-11, NCI-H1568 cells Concentration:0-1000 nM Incubation Time:3-7 days Result:Showed anti-proliferative activity with IC50 of 29, 68 nM for MV-4-11, NCI-H1568 cells, respectively.Apoptosis Analysis Cell Line:SK-MEL-5 cells Concentration:0.3 μM Incubation Time:100 hResult:Induced apoptosis in SK-MEL-5 cells.
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis|Epigenetic Reader Domain|PROTAC
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Research Area——
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Indication——
Chemical Information
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CAS Number2375564-55-7
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Formula Weight936.1
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Molecular FormulaC49H58FN9O7S
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (106.83 mM)
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SMILESCC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(C4(CC4)F)=O)=O)=O)C(OCCOC5=CC=C(CN6CCN(C7=CC(C8=C(O)C=CC=C8)=NN=C7N)CC6)C=C5)=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.
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