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NF-1819
CAS No. 1881244-28-5
NF-1819( —— )
Catalog No. M34346 CAS No. 1881244-28-5
NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 55 | In Stock |
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| 5MG | 55 | In Stock |
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| 10MG | 92 | In Stock |
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| 25MG | 188 | In Stock |
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| 50MG | 333 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNF-1819
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NoteResearch use only, not for human use.
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Brief DescriptionNF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor.
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DescriptionMGL-IN-1 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. MGL-IN-1 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. MGL-IN-1 displays high membrane permeability and brain penetrant.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetLipase
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RecptorLipase
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Research Area——
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Indication——
Chemical Information
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CAS Number1881244-28-5
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Formula Weight463.46
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Molecular FormulaC24H22FN5O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (134.86 mM; Ultrasonic )
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SMILES[H][C@@]1(N(C2CCN(CC2)C(=O)n2cncn2)C(=O)[C@]1([H])c1ccc(F)cc1)c1ccc2OCOc2c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Brindisi M, et al. Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. J Med Chem. 2016 Mar 24;59(6):2612-32. ?
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