LY 43578

CAS No. 26766-35-8

LY 43578( —— )

Catalog No. M34324 CAS No. 26766-35-8

LY 43578 is an orally active aromatase inhibitor. LY43578 could inhibit O-demethylation of P-450-dependent p-nitroanisole and N-demethylation of ethylmorphine (IC50 of 0.3 and 5 μm, respectively) in rat liver microsomes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LY 43578
  • Note
    Research use only, not for human use.
  • Brief Description
    LY 43578 is an orally active aromatase inhibitor. LY43578 could inhibit O-demethylation of P-450-dependent p-nitroanisole and N-demethylation of ethylmorphine (IC50 of 0.3 and 5 μm, respectively) in rat liver microsomes.
  • Description
    LY43578 is anorally active aromatase inhibitor. LY43578 inhibits P-450-dependent p-nitroanisole O-demethylation and ethylmorphine N-demethylation in hepatic microsomes isolated from rat, with the IC50 of 0.3 and 5 μΜ, respectively. LY43578 can be used for neurological disorder study.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    P450
  • Recptor
    P450 | Aromatase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    26766-35-8
  • Formula Weight
    331.2
  • Molecular Formula
    C17H12Cl2N2O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(O)(C1=CC=C(Cl)C=C1)(C2=CC=C(Cl)C=C2)C=3C=NC=NC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lindstrom TD, et al. Disposition of the aromatase inhibitor LY56110 and associated induction and inhibition studies in rats, dogs, and monkeys. Fundam Appl Toxicol. 1987;8(4):595-604.?
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