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JZP-361
CAS No. 1680193-80-9
JZP-361( —— )
Catalog No. M34301 CAS No. 1680193-80-9
JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 36 | In Stock |
|
| 10MG | 56 | In Stock |
|
| 25MG | 112 | In Stock |
|
| 50MG | 183 | In Stock |
|
| 100MG | 275 | In Stock |
|
| 200MG | 390 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJZP-361
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NoteResearch use only, not for human use.
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Brief DescriptionJZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6.
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DescriptionJZP-361 is a potent, reversible and selective inhibitor of human recombinant MAGL (hMAGL) with an IC50 of 46 nM. JZP-361 also shows antihistaminergic activities and can be used for asthma research.
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In VitroJZP-361 has almost 150-fold higher selectivity over human recombinant fatty acid amide hydrolase (hFAAH, IC50 = 7.24 μM) and 35-fold higher selectivity over human α/β-hydrolase-6 (hABHD6, IC50 = 1.79 μM).JZP-361 retains H1 antagonistic affinity (pA2 = 6.81) but did not show cannabinoid receptor activity, when tested at concentrations ≤10 μM.JZP-361 displays favorable interactions within the active site of hMAGL including the important hydrogen-bonding of the carbonyl oxygen to the oxyanion hole.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetLipase
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RecptorLipase
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Research Area——
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Indication——
Chemical Information
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CAS Number1680193-80-9
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Formula Weight405.88
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Molecular FormulaC22H20ClN5O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (307.97 mM; Ultrasonic (<60°C)
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SMILESClc1ccc2c(CCc3cccnc3C2=C2CCN(CC2)C(=O)n2cncn2)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jayendra Z Patel,?et al. Loratadine analogues as MAGL inhibitors. Bioorg Med Chem Lett.?2015 Apr 1;25(7):1436-42.?
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