INCB3619

Research use only, not for human use.

INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.

INCB3619 is a selective and orally active ADAM inhibitor with IC50 of 22 nM and 14 nM for ADAM10 and ADAM17, respectively. INCB3619 has anti-tumor activity.

Apoptosis Analysis.Cell Line:A549 cell Concentration:1, 10 μM Incubation Time:Result:Induced about 3% apoptosis at a concentration of 1 μM and about 5% at a concentration of 10 μM.Cell Viability Assay.Cell Line:NCI-H1666 cell Concentration:0-10 μM Incubation Time:72 h Result:Inhibited proliferation of NCI-H1666 cells.

Animal Model:BALB/c nu/nu mouse model of A549 xenograft Dosage:50, 60 mg/kg Administration:subcutaneous injection, daily, 14 d Result:Significant tumor growth inhibition and delay at 60 mg/kg dose, less active effect at 50 mg/kg.

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Others

Other Targets

Immunology/Inflammation related

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791826-72-7

413.47

C22H27N3O5

>98% (HPLC)

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C(NO)(=O)[C@H]1CC2(CN(C(OC)=O)[C@@H]1C(=O)N3CCC(=CC3)C4=CC=CC=C4)CC2

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(-20℃)

With Ice Pack

≥ 2 years