JC124

Research use only, not for human use.

JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.

JC124 is a specific NLRP3 inflammasome inhibitor. JC124 has anti-inflammatory and neuroprotective effects.

JC124 shows selective inhibition of NLRP3 inflammasome formation and activation of caspase-1, and reduction of IL-1β both in vitro.

JC124 (100?mg/kg; i.p.; 4 doses; 30?min post-injury, 6, 24, and 30?h after TBI) treatment significantly decreases the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume. JC124 also significantly reduces protein expression levels of NLRP3, ASC, IL-1 beta, TNFα, iNOS, and caspase-1.Animal Model:Adult male Sprague-Dawley rats (3-4-months-old) bearing traumatic brain injury (TBI) Dosage:100?mg/kg Administration:i.p.; 4 doses; 30?min post-injury, 6, 24, and 30?h after TBI Result:Significantly decreased the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume.

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NF-κB

NOD

NOD

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1638611-48-9

382.86

C17H19ClN2O4S

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (652.98 mM; Ultrasonic; (HCL ，pH≈3); )

CNS(=O)(=O)c1ccc(CCNC(=O)c2cc(Cl)ccc2OC)cc1

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(-20℃)

With Ice Pack

≥ 2 years