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NLRP3-IN-9
CAS No. 88039-46-7
NLRP3-IN-9( NLRP3 IN 9 | NLRP3IN9 | INF-4E | INF 4E | INF4E )
Catalog No. M27905 CAS No. 88039-46-7
NLRP3-IN-9 is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 76 | In Stock |
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| 5MG | 77 | In Stock |
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| 10MG | 123 | In Stock |
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| 25MG | 250 | In Stock |
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| 50MG | 398 | In Stock |
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| 100MG | 631 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNLRP3-IN-9
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NoteResearch use only, not for human use.
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Brief DescriptionNLRP3-IN-9 is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.
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DescriptionNLRP3-IN-9 is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.
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In VitroINF4E (compound 9) preventes both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.
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In VivoINF4E significantly reduces the in infarct size and lactate dehydrogenase release and improvement in postischemic left ventricular pressure.INF4E attenuates the formation of NLRP3 inflammasome complex was induced by myocardial IR (ischemia/reperfusion) in a time-dependent way.
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SynonymsNLRP3 IN 9 | NLRP3IN9 | INF-4E | INF 4E | INF4E
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PathwayNF-κB
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TargetNOD
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number88039-46-7
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Formula Weight240.68
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Molecular FormulaC12H13ClO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 100 mg/mL (415.49 mM)
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SMILESCCOC(=O)C(=C)C(O)c1ccccc1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Cooley RB, Sondermann H. Probing Protein-Protein Interactions with Genetically Encoded Photoactivatable Cross-Linkers. Methods Mol Biol. 2017;1657:331-345.
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