EMD57033

Research use only, not for human use.

EMD57033 is a cardiac troponin C (cTnC) activator, a dominant Ca2+ sensitizer, which functions by binding to cardiac/slow skeletal troponin C heterodimers to promote cardiac contraction.

(+)-EMD 57033 is a cardiac troponin C (cTnC) activator, is a dominant Ca2+ sensitizer. (+)-EMD 57033 binds the cardiac/slow skeletal troponin C isoform and exerts myocardial contractile promotion function.

(+)-EMD 57033 (30 μM) recovers the activation and sensitivity of Ca2+ in pig single muscle fibres and reduces VIDD (ventilator-induced diaphragm muscle fibre dysfunction) of .(+)-EMD 57033 (5.0-5.8 μM; 10-15 min) significantly increases the coronary blood flow and myocardial V?o2 (O2?consumption) in both 100 bpm and 150 bpm heart rates of rabbit heart, with a [Ca2+]0 concentration-dependent manner ([Ca2+]0=1.0 or 2.5 mM).(+)-EMD 57033 (5.0-5.8 μM; 10-15 min) increases left ventricular?(LV) end-diastolic pressure and prolongs relaxation.

(+)-EMD 57033 (0.4 or 0.8 mg/kg/min; i.v.drip; over than 20 min) enhances contractility and achieves Ca2+ sensitization in intact failing hearts at substantial energetic savings and without compromise of diastolic function in dogs.Animal Model:Mongrel dogs implanted with a micromanometer in left ventricle (LV) at the apex via lateral thoracotomy Dosage:0.4 or 0.8 mg/kg/min Administration:Intravenous drip; infused over 20 minutes Result:Enhanced contractility at both doses, with similar changes in CON (conscious dogs) and HF (heart failure dogs) hearts. Decreased the end-diastolic pressure (EDP) and lowered arterial load or preload at 0.8 mg/kg/min.

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Membrane Transporter/Ion Channel

Carbonic Anhydrase

Carbonic Anhydrase | Calcium Channel

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147527-31-9

425.5

C22H23N3O4S

>98% (HPLC)

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O=C(C1=CC(OC)=C(C=C1)OC)N2C3=CC=C(C([C@H](S4)C)=NNC4=O)C=C3CCC2

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(-20℃)

With Ice Pack

≥ 2 years