Cart
sales@molnova.com
SIRT6-IN-5
CAS No. 891002-11-2
SIRT6-IN-5( —— )
Catalog No. M34026 CAS No. 891002-11-2
SIRT6-IN-5（SIRT6 inhibitor 5） is a potent and selective SIRT6 inhibitor with an IC50 value of 34 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 78 | Get Quote |
|
| 5MG | 116 | Get Quote |
|
| 10MG | 187 | Get Quote |
|
| 25MG | 365 | Get Quote |
|
| 50MG | 725 | Get Quote |
|
| 100MG | 963 | Get Quote |
|
| 500MG | 1917 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameSIRT6-IN-5
-
NoteResearch use only, not for human use.
-
Brief DescriptionSIRT6-IN-5（SIRT6 inhibitor 5） is a potent and selective SIRT6 inhibitor with an IC50 value of 34 μM.
-
DescriptionSIRT6-IN-2 (Compound 5) is a selective SIRT6 inhibitor (IC50: 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayChromatin/Epigenetic
-
TargetSirtuin
-
RecptorSirtuin
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number891002-11-2
-
Formula Weight366.32
-
Molecular FormulaC19H14N2O6
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 62.5 mg/mL (170.62 mM; Ultrasonic )
-
SMILESN(C(=O)C1=CC=C(NC(=O)C2=CC=CO2)C=C1)C3=CC(C(O)=O)=C(O)C=C3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Damonte P, et al. SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects. Bioorg Med Chem. 2017 Oct 15;25(20):5849-5858.?
molnova catalog
related products
-
Octyl gallate
Octyl Gallate is an antioxidant approved by the US Food and Drug Administration (FDA) as a food additive. Octyl Gallate has antimetastatic activity.
-
JGB1741
JGB1741 is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleavage and increases the acetylated p53 levels leading to p53-mediated apoptosis. JGB1741 can be used in studies about breast cancer.
-
Sirtuin-1 inhibitor ...
Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.
