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KLH45
CAS No. 1632236-44-2
KLH45( —— )
Catalog No. M33995 CAS No. 1632236-44-2
KLH45 is an effective and selective inhibitor of Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2(IC50 = 1.3 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
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| 10MG | 37 | In Stock |
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| 25MG | 74 | In Stock |
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| 50MG | 116 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameKLH45
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NoteResearch use only, not for human use.
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Brief DescriptionKLH45 is an effective and selective inhibitor of Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2(IC50 = 1.3 nM).
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DescriptionKLH45 is a potent and selective DDHD2 inhibitor, with an IC50 of 1.3 nM.
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In VitroKLH45 (25 nM, 4 h) completely inactivats DDHD2 (>95% inhibition) in Neuro2A cells and shows no cross-reactivity with any of the other 40+ detected serine hydrolases with the exception of ABHD6.KLH45 (2 μM) increases LD formation in fatty acid-supplemented DDHD2-expressing cells.Cell Viability Assay Cell Line:COS-7 cells.Concentration:2 μM.Incubation Time:16 h.Result:Selectively blocked DDHD2 activity.
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In VivoKLH45 (20 mg/kg; administered every 12 h) for a total of 4 d exhibits significant elevations in several of the TAGs that accumulated in the brains of DDHD2?/? mice.Animal Model:Mice.Dosage:5-40 mg/kg.Administration:IP, once.Result:Did not show altered brain TAGs.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPhosphatase
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RecptorPhosphatase
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Research Area——
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Indication——
Chemical Information
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CAS Number1632236-44-2
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Formula Weight458.48
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Molecular FormulaC24H25F3N4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (218.11 mM; Ultrasonic )
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SMILESFC(F)(F)Oc1ccc(cc1)-c1cnn(n1)C(=O)N(CCc1ccccc1)C1CCCCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jordon M Inloes, et al. The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14924-9.?
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