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GSK854
CAS No. 1316059-00-3
GSK854( —— )
Catalog No. M33986 CAS No. 1316059-00-3
GSK854 is a highly selective and potent inhibitor of troponin I interacting kinase (TNNI3K) that inhibits myocardial infarction-injured cellular pyroptosis and apoptosis in mice, which may limit oxidative stress, injury, and adverse remodeling in the ischemic heart.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 258 | In Stock |
|
| 5MG | 235 | In Stock |
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| 10MG | 377 | In Stock |
|
| 25MG | 749 | In Stock |
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| 50MG | 1097 | In Stock |
|
| 100MG | 1739 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 3488 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGSK854
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NoteResearch use only, not for human use.
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Brief DescriptionGSK854 is a highly selective and potent inhibitor of troponin I interacting kinase (TNNI3K) that inhibits myocardial infarction-injured cellular pyroptosis and apoptosis in mice, which may limit oxidative stress, injury, and adverse remodeling in the ischemic heart.
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DescriptionGSK854 is a potent Inhibitor of Troponin I-Interacting Kinase (TNNI3K). GSK854 is a suitable lead for identifying new cardiac medicines and have been employed as in vivo tools in investigational studies aimed at defining the role of TNNI3K within heart failure.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number1316059-00-3
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Formula Weight482.96
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Molecular FormulaC18H19ClN6O4S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (517.64 mM; Ultrasonic )
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SMILESCCS(=O)(=O)c1ccc(cc1Nc1cc(Nc2ccc(Cl)cn2)ncn1)S(=O)(=O)NC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Philp J, et al. 4,6-Diaminopyrimidines as Highly Preferred Troponin I-Interacting Kinase (TNNI3K) Inhibitors. J Med Chem. 2018;61(7):3076-3088.?
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