Cart
sales@molnova.com
Ponatinib Hydrochloride
CAS No. 1114544-31-8
Ponatinib Hydrochloride( —— )
Catalog No. M33966 CAS No. 1114544-31-8
Ponatinib Hydrochloride (AP-24534 Hydrochloride) is a hydrochloride of ponatinib.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 37 | In Stock |
|
| 25MG | 68 | In Stock |
|
| 50MG | 105 | In Stock |
|
| 100MG | 160 | In Stock |
|
| 200MG | 237 | In Stock |
|
| 500MG | 403 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePonatinib Hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionPonatinib Hydrochloride (AP-24534 Hydrochloride) is a hydrochloride of ponatinib.
-
DescriptionPonatinib (AP24534) hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively. Ponatinib (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayAngiogenesis
-
TargetSrc
-
RecptorSrc | PDGFR | VEGFR | FGFR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1114544-31-8
-
Formula Weight569.02
-
Molecular FormulaC29H28ClF3N6O
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 25 mg/mL (43.94 mM; Ultrasonic (<60°C)
-
SMILESCl.CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. O'Hare T, et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell, 2009, 16(5), 401-412.?
molnova catalog
related products
-
KB SRC 4
KB SRC 4 is a selective and potent c-Src inhibitor with antitumour activity that inhibits the growth of cancer cells.
-
Saracatinib
A potent, highly selective, orally available, dual Src/Abl kinase inhibitor with IC50 of 2.7, 4, 4 and 30 nM for c-Src, Yes, Lck and Abl, respectively.
-
CH6953755
CH6953755 is an orally active, potent and selective YES1 kinase inhibitor (IC50:1.8 nM).CH6953755 has anticancer activity and inhibits cancer cell proliferation by inhibiting YES1 kinase.
